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Guardian: An Agentic AI for Proactive Critical Care Monitoring and Sepsis Prediction

12/11/2024 • NEJM AI • License: CC BY
Singh, R.

Abstract

We developed 'Guardian,' an agentic AI system for the ICU that autonomously monitors real-time physiological data streams. Guardian is designed to not only predict clinical deterioration but to also reason about the underlying causes and suggest next steps. In a simulated environment, it predicted the onset of sepsis a median of 6.2 hours earlier than the hospital's existing early warning system and provided actionable intervention checklists.

Clinical implications

A new AI agent for the ICU, called 'Guardian,' can monitor patient data and predict the life-threatening condition sepsis more than 6 hours earlier than current methods. Importantly, it also explains its reasoning and suggests what actions the clinical team should take next.

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